The overall aim of this Seminar is to provide a forum for the presentation, discussion, and formation in state-of-the-art research on personalized management of OSA. Specifically, the objectives are: to provide an update in basic research in animal and cellular models of the deleterious effects of OSA. Discuss the contribution of different signals associated with OSA, OMICS data and artificial intelligence systems to improve the risk stratification in OSA Analyse the most recent data on OSA endotypes and their different vulnerability to OSA comorbidities.