In line with the REG’s purpose to promote real-life research in respiratory diseases and the improvement of patient care through the influence of guidelines with real-world evidence, the Scientific Programme Committee has developed a rich scientific program, focusing on hot topics and controversial issues that can be meaningfully informed by real-life research. By bringing together top experts in respiratory medicine, and structuring the meeting around debate and think-tank sessions, REG Summit 2019 will provide the ideal ground for intellectual exchange and production of breakthrough ideas, among those passionate about understanding and treating respiratory diseases. It will be a highly educational experience complemented by ample networking and best-practice exchange opportunities.