This course aims to provide participants with the theoretical foundations for managing patients with multidrug-resistant tuberculosis (MDR-TB) and addresses, in a practical way, strategies for screening, preventing, and treating MDR-TB based on the latest evidence. The latest WHO recommendations will be discussed, as well as the choice of treatment regimens and the conditions for their application. The course will also introduce some elements of the management of extensively drug-resistant tuberculosis (XDR-TB).