The International Clinical and Programmatic TB-HIV Course aims to improve diagnosis, treatment and care of tuberculosis among people living with HIV. Mortality in co-infected patients is often very high and not all programmes are adapted to give an effective response on this reality. We believe that to reduce mortality in co-infected patients, it is necessary to offer an integrated clinical management to harmonise the management of both diseases and their complications under framework of the 12 points components of the country-level implementation of collaborative TB-HIV activities.